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Identification of Leukocyte Surface P2X7 as a Biomarker Associated with Alzheimer’s Disease

17 Jul 2022

Abstract excerpt

Alzheimer’s disease (AD) has shown altered immune responses in the periphery. We studied P2X7 (a proinflammatory receptor and a scavenger receptor) and two integrins, CD11b and CD11c, on the surface of circulating leukocytes and analysed their associations with Aβ-PET, brain atrophy, neuropsychological assessments, and cerebrospinal fluid (CSF) biomarkers. Total 287 age-matched, sex-balanced participants were...

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PMID: 35887215
DOI: 10.3390/ijms23147867

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