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Article

Possible protective role of the 489C>T P2X7R polymorphism in Alzheimer's disease.

Experimental gerontology - 1 Dec 2014

Sanz Juana M, Falzoni Simonetta, Rizzo Roberta, Cipollone Francesco, Zuliani Giovanni, Di Virgilio Francesco

Abstract excerpt

Inflammation is a key factor in the onset and progression of Alzheimer's disease (AD). The P2X7 receptor (P2X7R) is increasingly recognized as key pro-inflammatory receptor. A recent study has shown that activation of microglia by amyloid β (Aβ) and associated release of IL-1β, requires P2X7R expression. In this study we assessed by RT-PCR in genomic DNA samples, the frequency of two single-nucleotide...

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Identifiers

PMID: 25456845
DOI: 10.1016/j.exger.2014.10.009
PMCID: PMC4266448

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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