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Article

NRF2 Augments Epidermal Antioxidant Defenses and Promotes Atopy

20 Jul 2020

Abstract excerpt

Atopic dermatitis is a chronic form of allergic contact dermatitis that is closely associated with a compromised epidermal barrier. Immunogenicity of a given electrophilic hapten after penetration of this barrier depends directly on biochemical reactions in the thiol-rich layer in the stratum granulosum. In response to electrophilic hapten, NF-erythroid 2-related factor 2 (NRF2) in keratinocytes efficiently...

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Share to Allergic Rhinitis and Sensitization
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Identifiers

PMID: 32690656
DOI: 10.4049/jimmunol.2000274

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