Article
Genome-wide transcriptional analyses of Chinese patients reveal cell migration is attenuated in IDH1-mutant glioblastomas.
Cancer letters - 28 Feb 2015
Hu Huimin, Wang Zheng, Liu Yanwei, Zhang Chuanbao, Li Mingyang, Zhang Wenlong, Wang Kuanyu, Cai Jinquan, Cheng Wen, Huang Hua, Jiang Tao
Abstract excerpt
Patients with isocitrate dehydrogenase 1 (IDH1)-mutant glioblastoma exhibit increased survival compared with those with wild-type IDH1 tumors. The magnitude of this finding has led to the use of IDH1 mutations as diagnostic and prognostic biomarkers. However, the mechanisms underlying the reported correlation between the IDH1 mutation and increased survival have not been fully revealed. In this work, based on...
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