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Article

Tissue mechanics promote IDH1-dependent HIF1α-tenascin C feedback to regulate glioblastoma aggression.

Nature cell biology - 1 Dec 2016

Miroshnikova Yekaterina A, Mouw Janna K, Barnes J Matthew, Pickup Michael W, Lakins Johnathan N, Kim Youngmi, Lobo Khadjia, Persson Anders I, Reis Gerald F, McKnight Tracy R, Holland Eric C, Phillips Joanna J, Weaver Valerie M

Abstract excerpt

Increased overall survival for patients with glioma brain tumours is associated with mutations in the metabolic regulator isocitrate dehydrogenase 1 (IDH1). Gliomas develop within a mechanically challenged microenvironment that is characterized by a dense extracellular matrix (ECM) that compromises vascular integrity to induce hypoxia and activate HIF1α. We found that glioma aggression and patient prognosis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 27820599
DOI: 10.1038/ncb3429
PMCID: PMC5361403

Genes

IDH1
TNC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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