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Article

Chronic nitric oxide exposure induces prostate cell carcinogenesis, involving genetic instability and a pro-tumorigenic secretory phenotype.

Nitric oxide : biology and chemistry - 1 Oct 2022

Burke Amy J, McAuliffe Jake D, Natoni Alessandro, Ridge Sarah, Sullivan Francis J, Glynn Sharon A

Abstract excerpt

Prostate cancer is a leading cause of cancer death in men. Inflammation and overexpression of inducible nitric oxide synthase (NOS2) have been implicated in prostate carcinogenesis. We aimed to explore the hypothesis that nitric oxide NO exerts pro-tumorigenic effects on prostate cells at physiologically relevant levels contributing to carcinogenesis. We investigated the impact of acute exposure of normal...

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PMID: 35872082
DOI: 10.1016/j.niox.2022.07.005

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