Article

Identification and prioritization of gene sets associated with schizophrenia risk by co-expression network analysis in human brain

2018-03-23

Abstract excerpt

Schizophrenia polygenic risk is plausibly manifested by complex transcriptional dysregulation in the brain, involving networks of co-expressed and functionally related genes. The main purpose of this study was to identify and prioritize co-expressed gene sets in a hierarchical manner, based on the strength of the relationships with clinical diagnosis and with the polygenic risk for schizophrenia. Weighted Gene Co-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c65ad24a-dc82-599b-9722-ceee6202f7f0
DOI: 10.1101/286559

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification and prioritization of gene sets associated with schizophrenia risk by co-expression network analysis in human brainDOI 10.1101/286559Read

Prefrontal co-expression of schizophrenia risk genes is associated with treatment response in patientsSemantic proximity Read

Investigating trait variability of gene co-expression network architecture in brain by manipulating genomic signatures of schizophrenia riskSemantic proximity Read

Genes with disrupted connectivity in the architecture of schizophrenia gene co-expression networks highlight atypical neuronal-glial interactionsSemantic proximity Read

Two gene co-expression modules differentiate psychotics and controls.Semantic proximity Read

Investigating trait variability of gene co-expression network architecture in brain by controlling for genomic risk of schizophrenia.Semantic proximity Read

Network-wide risk convergence in gene co-expression identifies reproducible genetic hubs of schizophrenia risk.Semantic proximity Read

Identification of relevant hub genes for early intervention at gene coexpression modules with altered predicted expression in schizophrenia.Semantic proximity Read

DRD2 co-expression network and a related polygenic index predict imaging, behavioral and clinical phenotypes linked to schizophrenia.Semantic proximity Read

DLPFC Transcriptome Defines Two Molecular Subtypes of SchizophreniaSemantic proximity Read

Association of astrocyte-specific gene expression in the dorsolateral prefrontal cortex with treatment-resistant schizophreniaSemantic proximity Read

Limited Association between Schizophrenia Genetic Risk Factors and Transcriptomic Features.Semantic proximity Read

DLPFC transcriptome defines two molecular subtypes of schizophreniaSemantic proximity Read