Article
NURR1 and ERR1 Modulate the Expression of Genes of a DRD2 Coexpression Network Enriched for Schizophrenia Risk.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 22 Jan 2020
Torretta Silvia, Rampino Antonio, Basso Manuela, Pergola Giulio, Di Carlo Pasquale, Shin Joo H, Kleinman Joel E, Hyde Thomas M, Weinberger Daniel R, Masellis Rita, Blasi Giuseppe, Pennuto Maria, Bertolino Alessandro
Abstract excerpt
Multiple schizophrenia (SCZ) risk loci may be involved in gene co-regulation mechanisms, and analysis of coexpressed gene networks may help to clarify SCZ molecular basis. We have previously identified a dopamine D2 receptor (DRD2) coexpression module enriched for SCZ risk genes and associated with cognitive and neuroimaging phenotypes of SCZ, as well as with response to treatment with antipsychotics. Here we...
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