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Article

Multilocus genetic profile in dopaminergic pathway modulates the striatum and working memory.

Scientific reports - 29 Mar 2018

Wang Chao, Liu Bing, Zhang Xiaolong, Cui Yue, Yu Chunshui, Jiang Tianzi

Abstract excerpt

Dopamine is critical in pathophysiology and therapy of schizophrenia. Many studies have reported altered dopaminergic activity in the dorsal but not ventral striatum in schizophrenia. Based on the largest genome-wide association study of schizophrenia to date, we calculated the polygenic risk score (PGRS) of each subject in a healthy general group, including all variations in the set of functionally related genes...

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Identifiers

PMID: 29599495
DOI: 10.1038/s41598-018-23191-y
PMCID: PMC5876382

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