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Genetic susceptibility to schizophrenia: role of dopaminergic pathway gene polymorphisms.

Pharmacogenomics - 1 Feb 2009

Gupta Meenal, Chauhan Chitra, Bhatnagar Pallav, Gupta Simone, Grover Sandeep, Singh Prashant K, Purushottam Meera, Mukherjee Odity, Jain Sanjeev, Brahmachari Samir K, Kukreti Ritushree

Abstract excerpt

AIM: We investigated 16 polymorphisms from three genes, dopamine receptor D2 (DRD2), catechol-O-methyl transferase (COMT) and brain derived neurotrophic factor (BDNF), which are involved in the dopaminergic pathways, and have been reported to be associated with susceptibility to schizophrenia and response to antipsychotic therapy. MATERIALS & METHODS: Single-locus association analyses of these polymorphisms were...

Topics

Adult
Amino Acid Substitution
Brain-Derived Neurotrophic Factor
Case-Control Studies
Catechol O-Methyltransferase
Exons
Female
Genetic Predisposition to Disease
Genetic Variation
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

India

Male

Polymorphism, Genetic

Polymorphism, Single Nucleotide

Receptors, Dopamine D3

Reference Values

Schizophrenia

Young Adult

Source

Identifiers

PMID: 19207030
DOI: 10.2217/14622416.10.2.277

Genes

COMT
DRD2
BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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