Article
Synonymous mutation rs1129293 is associated with PIK3CG expression and PI3Kγ activation in patients with chronic Chagas cardiomyopathy.
Immunobiology - 1 Sept 2022
Silva Maria Cláudia, Fuzo Carlos Alessandro, Marques Paiva Isadora, Lopes Bibó Naira, Tavares de Oliveira Maykon, da Silva Soares Hellen Anastácia, Chevillard Christophe, Kalil Jorge, Cunha-Neto Edecio, Cunha Thiago Mattar, Silva João Santana
Abstract excerpt
Single nucleotide polymorphisms (SNPs) that do not change the composition of amino acids and cause synonymous mutations (sSNPs) were previously considered to lack any functional roles. However, sSNPs have recently been shown to interfere with protein expression owing to a myriad of factors related to the regulation of transcription, mRNA stability, and protein translation processes. In patients with Chagas...
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