Systematic search for single nucleotide polymorphisms in the 5' flanking region of the human phosphodiesterase 3B gene: absence of evidence for major effects of identified polymorphisms on susceptibility to Japanese type 2 diabetes.

doi:10.1016/s1096-7192(03)00035-0

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Systematic search for single nucleotide polymorphisms in the 5' flanking region of the human phosphodiesterase 3B gene: absence of evidence for major effects of identified polymorphisms on susceptibility to Japanese type 2 diabetes.

Molecular genetics and metabolism - 1 May 2003

Osawa Haruhiko, Niiya Toshiyuki, Onuma Hiroshi, Murakami Akiko, Ochi Masaaki, Nishimiya Tatsuya, Ogura Takahiro, Kato Kenichi, Shimizu Ikki, Fujii Yasuhisa, Ohashi Jun, Yamada Kazuya, Liang Shu-Jian, Manganiello Vincent C, Fujita-Yamaguchi Yoko, Makino Hideichi

Abstract excerpt

The activation of phosphodiesterase 3B (PDE3B) reduces free fatty acid output from adipocytes. A reduced PDE3B gene expression could lead to insulin resistance. To determine whether there are polymorphisms associated with type 2 diabetes in PDE3B gene promoter, this 5(') flanking region was isolated. The transcription initiation site was located 206bp upstream from the translation start site. Sequences of 2kb of...

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PMID: 12765845
DOI: 10.1016/s1096-7192(03)00035-0

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