Article
Systematic search for single nucleotide polymorphisms in the 5' flanking region of the human phosphodiesterase 3B gene: absence of evidence for major effects of identified polymorphisms on susceptibility to Japanese type 2 diabetes.
Molecular genetics and metabolism - 1 May 2003
Osawa Haruhiko, Niiya Toshiyuki, Onuma Hiroshi, Murakami Akiko, Ochi Masaaki, Nishimiya Tatsuya, Ogura Takahiro, Kato Kenichi, Shimizu Ikki, Fujii Yasuhisa, Ohashi Jun, Yamada Kazuya, Liang Shu-Jian, Manganiello Vincent C, Fujita-Yamaguchi Yoko, Makino Hideichi
Abstract excerpt
The activation of phosphodiesterase 3B (PDE3B) reduces free fatty acid output from adipocytes. A reduced PDE3B gene expression could lead to insulin resistance. To determine whether there are polymorphisms associated with type 2 diabetes in PDE3B gene promoter, this 5(') flanking region was isola...
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