Article
Polymorphism in the catalytic subunit of the PI3Kγ gene is associated with Trypanosoma cruzi-induced chronic chagasic cardiomyopathy.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Mar 2021
Silva Maria Cláudia, da Silva Medina Tiago, Fuzo Carlos Alessandro, Dias Fabrício Cesar, Freitas-Castro Felipe, Fukutani Kiyoshi Ferreira, Donadi Eduardo Antônio, Cunha-Neto Edecio, Cunha Thiago Mattar, Silva João Santana
Abstract excerpt
Chagas disease is caused by the protozoan parasite Trypanosoma cruzi. During the chronic phase of disease, while most infected people do not present symptoms, characterizing the asymptomatic form, some patients develop the cardiac form or chronic chagasic cardiomyopathy, which is considered the most severe manifestation of this disease. Considering that the activation of the PI3Kγ signaling pathway is essential...
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