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Article

GWAS loci associated with Chagas cardiomyopathy influences DNA methylation levels.

PLoS neglected tropical diseases - 1 Oct 2021

Casares-Marfil Desiré, Kerick Martin, Andrés-León Eduardo, Bosch-Nicolau Pau, Molina Israel, Martin Javier, Acosta-Herrera Marialbert

Abstract excerpt

A recent genome-wide association study (GWAS) identified a locus in chromosome 11 associated with the chronic cardiac form of Chagas disease. Here we aimed to elucidate the potential functional mechanism underlying this genetic association by analyzing the correlation among single nucleotide polymorphisms (SNPs) and DNA methylation (DNAm) levels as cis methylation quantitative trait loci (cis-mQTL) within this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34714828
DOI: 10.1371/journal.pntd.0009874
PMCID: PMC8580254

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