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Article

Variation in the Phosphoinositide 3-Kinase Gamma Gene Affects Plasma HDL-Cholesterol without Modification of Metabolic or Inflammatory Markers.

PloS one - 1 Jan 2015

Kächele Martin, Hennige Anita M, Machann Jürgen, Hieronimus Anja, Lamprinou Apostolia, Machicao Fausto, Schick Fritz, Fritsche Andreas, Stefan Norbert, Nürnberg Bernd, Häring Hans-Ulrich, Staiger Harald

Abstract excerpt

OBJECTIVE: Phosphoinositide 3-kinase γ (PI3Kγ) is a G-protein-coupled receptor-activated lipid kinase mainly expressed in leukocytes and cells of the cardiovascular system. PI3Kγ plays an important signaling role in inflammatory processes. Since subclinical inflammation is a hallmark of atherosclerosis, obesity-related insulin resistance, and pancreatic β-cell failure, we asked whether common genetic variation in...

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Identifiers

PMID: 26658747
DOI: 10.1371/journal.pone.0144494
PMCID: PMC4675530

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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