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Article

RHOX10 drives mouse spermatogonial stem cell establishment through a transcription factor signaling cascade

1 Jul 2021

Abstract excerpt

Spermatogonial stem cells (SSCs) are essential for male fertility. Here, we report that mouse SSC generation is driven by a transcription factor (TF) cascade controlled by the homeobox protein, RHOX10, which acts by driving the differentiation of SSC precursors called pro-spermatogonia (ProSG). We identify genes regulated by RHOX10 in ProSG in vivo and define direct RHOX10-target genes using several approaches,...

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PMID: 34289349
DOI: 10.1016/j.celrep.2021.109423

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