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The testis-specific E3 ubiquitin ligase RNF133 is required for fecundity in mice

13 Jul 2022

Abstract excerpt

BACKGROUND: Ubiquitination is a post-translational modification required for a number of physiological functions regulating protein homeostasis, such as protein degradation. The endoplasmic reticulum (ER) quality control system recognizes and degrades proteins no longer needed in the ER through the ubiquitin-proteasome pathway. E2 and E3 enzymes containing a transmembrane domain have been shown to function in ER...

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PMID: 35831855
DOI: 10.1186/s12915-022-01368-2

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