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Article

Estimation of causal effects of a time-varying exposure at multiple time points through multivariable mendelian randomization.

PLoS genetics - 1 Jul 2022

Sanderson Eleanor, Richardson Tom G, Morris Tim T, Tilling Kate, Davey Smith George

Abstract excerpt

Mendelian Randomisation (MR) is a powerful tool in epidemiology that can be used to estimate the causal effect of an exposure on an outcome in the presence of unobserved confounding, by utilising genetic variants as instrumental variables (IVs) for the exposure. The effect estimates obtained from MR studies are often interpreted as the lifetime effect of the exposure in question. However, the causal effects of...

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PMID: 35849575
DOI: 10.1371/journal.pgen.1010290
PMCID: PMC9348730

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