Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cell Surface Calcium-Sensing Receptor Heterodimers: Mutant Gene Dosage Affects Ca2+ Sensing but Not G Protein Interaction.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Sept 2022

Goolam Mahvash A, Brown Alice P, Edwards Kimberly T, Gregory Karen J, Leach Katie, Conigrave Arthur D

Abstract excerpt

The calcium-sensing receptor is a homodimeric class C G protein-coupled receptor (GPCR) that senses extracellular Ca2+ (Ca2+ o ) via a dimeric extracellular Venus flytrap (VFT) unit that activates G protein-dependent signaling via twin Cysteine-rich domains linked to transmembrane heptahelical (HH) bundles. It plays a key role in the regulation of human calcium and thus mineral metabolism. However, the nature of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium
Share to gamma-Aminobutyric Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Dosage

Share to HEK293 Cells

Share to Hypercalcemia

Share to Hyperparathyroidism, Primary

Share to Infant, Newborn

Share to Receptors, Calcium-Sensing

Source

Open in PubMed Open full text

Identifiers

PMID: 35848051
DOI: 10.1002/jbmr.4651
PMCID: PMC9545990

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cell Surface Calcium-Sensing Receptor Heterodimers: Mutant Gene Dosage Affects Ca2+ Sensing but Not G Protein Interaction.PMID 35848051Read ↗

Reduced affinity of calcium sensing-receptor heterodimers and reduced mutant homodimer trafficking combine to impair function in a model of familial hypocalciuric hypercalcemia type 1.Semantic proximity Read ↗

Reduced affinity of calcium sensing-receptor heterodimers and reduced mutant homodimer trafficking combine to impair function in a mouse model of Familial Hypocalciuric Hypercalcemia Type 1Semantic proximity Read ↗

Identification of molecular phenotypes and biased signaling induced by naturally occurring mutations of the human calcium-sensing receptor.Semantic proximity Read ↗

Structure and function of the human calcium-sensing receptor: insights from natural and engineered mutations and allosteric modulators.Semantic proximity Read ↗

Recent advances in calcium-sensing receptor structures and signaling pathways.Semantic proximity Read ↗

Naturally occurring mutations of the extracellular Ca2+-sensing receptor: implications for its structure and function.Semantic proximity Read ↗

Disorders of the calcium-sensing receptor and partner proteins: insights into the molecular basis of calcium homeostasis.Semantic proximity Read ↗

Both calcium-sensing receptor intracellular C-terminal domains support homodimer signaling.Semantic proximity Read ↗

Novel Activating Mutations of the Calcium-Sensing Receptor: The Calcilytic NPS-2143 Mitigates Excessive Signal Transduction of Mutant ReceptorsSemantic proximity Read ↗

AP2σ Mutations Impair Calcium-Sensing Receptor Trafficking and Signaling, and Show an Endosomal Pathway to Spatially Direct G-Protein Selectivity.Semantic proximity Read ↗

A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin-biased signaling.Semantic proximity Read ↗

Calcium signaling regulates trafficking of familial hypocalciuric hypercalcemia (FHH) mutants of the calcium sensing receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.