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Article

Both calcium-sensing receptor intracellular C-terminal domains support homodimer signaling.

Molecular pharmacology - 1 Nov 2025

Binmahfouz Lenah S, Goolam Mahvash A, Barker Eleanor, Conigrave Arthur D, Ward Donald T

Abstract excerpt

Extracellular calcium-sensing receptors (CaSRs) are required for whole-body calcium homeostasis and operate as homodimers, shown structurally to bind only one heterotrimeric G protein at a time. Whether the intracellular domain (ICD) of the other, uncoupled monomer is functionally redundant or still required for optimal CaSR signaling remains unknown. Cotransfection of human embryonic kidney 293 cells with...

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Identifiers

PMID: 41130021
DOI: 10.1016/j.molpha.2025.100077
PMCID: PMC12799464

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