Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

AP2σ Mutations Impair Calcium-Sensing Receptor Trafficking and Signaling, and Show an Endosomal Pathway to Spatially Direct G-Protein Selectivity.

Cell reports - 23 Jan 2018

Gorvin Caroline M, Rogers Angela, Hastoy Benoit, Tarasov Andrei I, Frost Morten, Sposini Silvia, Inoue Asuka, Whyte Michael P, Rorsman Patrik, Hanyaloglu Aylin C, Breitwieser Gerda E, Thakker Rajesh V

Abstract excerpt

Spatial control of G-protein-coupled receptor (GPCR) signaling, which is used by cells to translate complex information into distinct downstream responses, is achieved by using plasma membrane (PM) and endocytic-derived signaling pathways. The roles of the endomembrane in regulating such pleiotropic signaling via multiple G-protein pathways remain unknown. Here, we investigated the effects of disease-causing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Protein Complex 2
Share to Calcium Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endosomes

Share to GTP-Binding Proteins

Share to Mutation

Share to Receptors, Calcium-Sensing

Source

Open in PubMed Open full text

Identifiers

PMID: 29420171
DOI: 10.1016/j.celrep.2017.12.089
PMCID: PMC5792449

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

AP2σ Mutations Impair Calcium-Sensing Receptor Trafficking and Signaling, and Show an Endosomal Pathway to Spatially Direct G-Protein Selectivity.PMID 29420171Read ↗

Mutations in AP2S1 cause familial hypocalciuric hypercalcemia type 3.Semantic proximity Read ↗

Disorders of the calcium-sensing receptor and partner proteins: insights into the molecular basis of calcium homeostasis.Semantic proximity Read ↗

Minireview: The Intimate Link Between Calcium Sensing Receptor Trafficking and Signaling: Implications for Disorders of Calcium HomeostasisSemantic proximity Read ↗

Endocytic Adaptor Proteins in Health and Disease: Lessons from Model Organisms and Human Mutations.Semantic proximity Read ↗

Ap2s1 mutation causes hypercalcaemia in mice and impairs interaction between calcium-sensing receptor and adaptor protein-2.Semantic proximity Read ↗

Calcium signaling regulates trafficking of familial hypocalciuric hypercalcemia (FHH) mutants of the calcium sensing receptor.Semantic proximity Read ↗

Large-scale exome datasets reveal a new class of adaptor-related protein complex 2 sigma subunit (AP2σ) mutations, located at the interface with the AP2 alpha subunit, that impair calcium-sensing receptor signalling.Semantic proximity Read ↗

Novel Activating Mutations of the Calcium-Sensing Receptor: The Calcilytic NPS-2143 Mitigates Excessive Signal Transduction of Mutant ReceptorsSemantic proximity Read ↗

Mutations affecting G-protein subunit α11 in hypercalcemia and hypocalcemia.Semantic proximity Read ↗

Loss of phosphorylation sites required for β-arrestin recruitment in the calcium-sensing receptor cytoplasmic region may contribute to hypocalcemiaSemantic proximity Read ↗

When calcium goes wrong: genetic alterations of a ubiquitous signaling route.Semantic proximity Read ↗

The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.