Article
A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin-biased signaling.
Science signaling - 20 Feb 2018
Gorvin Caroline M, Babinsky Valerie N, Malinauskas Tomas, Nissen Peter H, Schou Anders J, Hanyaloglu Aylin C, Siebold Christian, Jones E Yvonne, Hannan Fadil M, Thakker Rajesh V
Abstract excerpt
The calcium-sensing receptor (CaSR) is a G protein-coupled receptor (GPCR) that signals through Gq/11 and Gi/o to stimulate cytosolic calcium (Ca2+i) and mitogen-activated protein kinase (MAPK) signaling to control extracellular calcium homeostasis. Studies of loss- and gain-of-function CASR mutations, which cause familial hypocalciuric hypercalcemia type 1 (FHH1) and autosomal dominant hypocalcemia type 1...
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