Article
Senescent Tumor Cells in the Peritoneal Carcinomatosis Drive Immunosenescence in the Tumor Microenvironment.
Frontiers in immunology - 1 Jan 2022
Braumüller Heidi, Mauerer Bernhard, Berlin Christopher, Plundrich Dorothea, Marbach Patrick, Cauchy Pierre, Laessle Claudia, Biesel Esther, Holzner Philipp Anton, Kesselring Rebecca
Abstract excerpt
More than half of all patients with colorectal cancer (CRC) develop distant metastasis and, depending on the local stage of the primary tumor, up to 48% of patients present peritoneal carcinomatosis (PC). PC is often considered as a widespread metastatic disease, which is almost resistant to current systemic therapies like chemotherapeutic and immunotherapeutic regimens. Here we could show that tumor cells of PC...
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