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The Senescent Side of Tumor Suppression

9 Nov 2005

Abstract excerpt

Neoplastic transformation of human cells is a rare event that requires overcoming anti-tumoral cellular responses. Oncogene-induced senescence (OIS) is considered a crucial tumor suppressor mechanism controlling unchecked proliferation driven by oncogenic mutation. However, the analysis of OIS has been restricted so far to cultured cells. Recently, we have identified novel molecular markers of OIS and we have...

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PMID: 16294043
DOI: 10.4161/cc.4.12.2260

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