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Article

Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases.

Cell death & disease - 29 Dec 2016

Mikuła-Pietrasik Justyna, Uruski Paweł, Sosińska Patrycja, Maksin Konstantin, Piotrowska-Kempisty Hanna, Kucińska Małgorzata, Murias Marek, Szubert Sebastian, Woźniak Aldona, Szpurek Dariusz, Sajdak Stefan, Piwocka Katarzyna, Tykarski Andrzej, Książek Krzysztof

Abstract excerpt

Although both incidence and aggressiveness of ovarian malignancy rise with age, the exact reason for this tendency, in particular the contribution of senescent cells, remains elusive. In this project we found that the patient's age determines the frequency of intraperitoneal metastases of ovarian cancer. Moreover, we documented that senescent human peritoneal mesothelial cells (HPMCs) stimulate proliferation,...

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Identifiers

PMID: 28032864
DOI: 10.1038/cddis.2016.417
PMCID: PMC5261005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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