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Article

Oncogenic BRAF induces whole-genome doubling through suppression of cytokinesis.

Nature communications - 15 Jul 2022

Darp Revati, Vittoria Marc A, Ganem Neil J, Ceol Craig J

Abstract excerpt

Melanomas and other solid tumors commonly have increased ploidy, with near-tetraploid karyotypes being most frequently observed. Such karyotypes have been shown to arise through whole-genome doubling events that occur during early stages of tumor progression. The generation of tetraploid cells via whole-genome doubling is proposed to allow nascent tumor cells the ability to sample various pro-tumorigenic genomic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35840569
DOI: 10.1038/s41467-022-31899-9
PMCID: PMC9287415

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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