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Article

Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution.

Cancer discovery - 1 Feb 2014

Dewhurst Sally M, McGranahan Nicholas, Burrell Rebecca A, Rowan Andrew J, Grönroos Eva, Endesfelder David, Joshi Tejal, Mouradov Dmitri, Gibbs Peter, Ward Robyn L, Hawkins Nicholas J, Szallasi Zoltan, Sieber Oliver M, Swanton Charles

Abstract excerpt

UNLABELLED: The contribution of whole-genome doubling to chromosomal instability (CIN) and tumor evolution is unclear. We use long-term culture of isogenic tetraploid cells from a stable diploid colon cancer progenitor to investigate how a genome-doubling event affects genome stability over time. Rare cells that survive genome doubling demonstrate increased tolerance to chromosome aberrations. Tetraploid cells do...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24436049
DOI: 10.1158/2159-8290.CD-13-0285
PMCID: PMC4293454

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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