Article
Genetic Variants Underlying Risk of Intracranial Aneurysms: Insights from a GWAS in Portugal.
PloS one - 1 Jan 2015
Abrantes Patrícia, Santos Maria M, Sousa Inês, Xavier Joana M, Francisco Vânia, Krug Tiago, Sobral João, Matos Mafalda, Martins Madalena, Jacinto António, Coiteiro Domingos, Oliveira Sofia A
Abstract excerpt
Subarachnoid hemorrhage (SAH) is a life-threatening event that most frequently leads to severe disability and death. Its most frequent cause is the rupture of a saccular intracranial aneurysm (IA), which is a blood vessel dilation caused by disease or weakening of the vessel wall. Although the genetic contribution to IA is well established, to date no single gene has been unequivocally identified as responsible...
Topics
- DNA
- Databases, Genetic
- Female
- Genetic Predisposition to Disease
- Genetic Variation
- Genome-Wide Association Study
- Humans
- Intracranial Aneurysm
- Male
- Middle Aged