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Article

Dissecting the Genetic Architecture of Intracranial Aneurysms.

Circulation. Genomic and precision medicine - 1 Jun 2025

Adkar Shaunak S, Lynch Julie, Choi Ryan B, Roychowdhury Tanmoy, Judy Renae L, Paruchuri Kaavya, Go Dong-Chuan, Bamezai Sharika, Cabot John, Sorondo Sabina, Levin Michael G, Milewicz Dianna M, Willer Cristen J, Natarajan Pradeep, Pyarajan Saiju, Chang Kyong-Mi, Damrauer Scott, Tsao Phil, Skirboll Stephen, Leeper Nicholas J, Klarin Derek

Abstract excerpt

BACKGROUND: The genetic risk of intracranial aneurysm (IA) development has been ascribed to the genetic risk of smoking exposure and hypertension. The relationship of IA to other cardiovascular traits and the contribution of IA risk loci to aberrant gene programs within cerebrovascular cell types remains unclear. METHODS: We performed a genome-wide association study in the Million Veteran Program and Finnish...

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Identifiers

PMID: 40255156
DOI: 10.1161/CIRCGEN.123.004626
PMCID: PMC12173771

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