Article
Common variant near the endothelin receptor type A (EDNRA) gene is associated with intracranial aneurysm risk.
Proceedings of the National Academy of Sciences of the United States of America - 6 Dec 2011
Yasuno Katsuhito, Bakırcıoğlu Mehmet, Low Siew-Kee, Bilgüvar Kaya, Gaál Emília, Ruigrok Ynte M, Niemelä Mika, Hata Akira, Bijlenga Philippe, Kasuya Hidetoshi, Jääskeläinen Juha E, Krex Dietmar, Auburger Georg, Simon Matthias, Krischek Boris, Ozturk Ali K, Mane Shrikant, Rinkel Gabriel J E, Steinmetz Helmuth, Hernesniemi Juha, Schaller Karl, Zembutsu Hitoshi, Inoue Ituro, Palotie Aarno, Cambien François, Nakamura Yusuke, Lifton Richard P, Günel Murat
Abstract excerpt
The pathogenesis of intracranial aneurysm (IA) formation and rupture is complex, with significant contribution from genetic factors. We previously reported genome-wide association studies based on European discovery and Japanese replication cohorts of 5,891 cases and 14,181 controls that identified five disease-related loci. These studies were based on testing replication of genomic regions that contained SNPs...
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