Article

Natural Killer cells demonstrate distinct eQTL and transcriptome-wide disease associations, highlighting their role in autoimmunity

2021-05-11

Abstract excerpt

Natural Killer (NK) cells are innate lymphocytes with central roles in immunosurveillance and are implicated in autoimmune pathogenesis. The degree to which regulatory variants affect NK gene expression is poorly understood. We performed expression quantitative trait locus (eQTL) mapping of negatively selected NK cells from a population of healthy Europeans (n=245). We find a significant subset of genes demonstrat...

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Literature Corpus work: 3282ac35-cd3a-5a8f-b368-0ae46a47ef09
DOI: 10.1101/2021.05.10.443088

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