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Article

KRAS mutation in intrahepatic cholangiocarcinoma: Linkage with metastasis-free survival and reduced E-cadherin expression.

Liver international : official journal of the International Association for the Study of the Liver - 1 Oct 2022

Tanaka Mariko, Kunita Akiko, Yamagishi Makoto, Katoh Hiroto, Ishikawa Shumpei, Yamamoto Hiroyuki, Abe Jun, Arita Junichi, Hasegawa Kiyoshi, Shibata Tatsuhiro, Ushiku Tetsuo

Abstract excerpt

BACKGROUND AND AIMS: Although KRAS mutations are the major driver of intrahepatic cholangiocarcinoma (ICC), their role remains unexplored. This study aimed to elucidate the prognostic effects, association with clinicopathologic characteristics and potent functions of KRAS mutations in ICC. METHODS: A hundred and seven resected stage I-III ICCs were analysed for KRAS mutation status and its link with...

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Identifiers

PMID: 35833881
DOI: 10.1111/liv.15366

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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