Article
Identifying a Common Autoimmune Gene Core as a Tool for Verifying Biological Significance and Applicability of Polygenic Risk Scores.
International journal of molecular sciences - 5 Jan 2026
Shchekina Victoria Sergeevna, Batashkov Nikita Aleksandrovich, Maznina Anna Arkadievna, Krupinova Julia Aleksandrovna, Bogdanov Viktor Pavlovich, Korobeinikova Anna Vasilievna, Tychinin Dmitry Igorevich, Glushkova Olga Valentinovna, Petriaikina Ekaterina Sergeevna, Svetlichnyy Dmitry Vladimirovich, Woroncow Mary, Yudin Vladimir Sergeevich, Keskinov Anton Arturovich, Yudin Sergey Mikhailovich, Skvortsova Veronika Igorevna, Tabakov Dmitry Vyacheslavovich, Deviatkin Andrei Andreevich, Volchkov Pavel Yu
Abstract excerpt
Polygenic autoimmune diseases (ADs) have several common features that are caused by a complex interplay of genetic and environmental factors. Common pathophysiological mechanisms include dysregulation of the immune system, chronic inflammation, and epigenetic changes influenced by external factors. For the prediction of the genetic predisposition of AD manifestation, polygenic risk scale (PRS), or polygenic...
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