Article
Epigenetic modulators of B cell fate identified through coupled phenotype-transcriptome analysis.
Cell death and differentiation - 1 Dec 2022
Kong Isabella Y, Trezise Stephanie, Light Amanda, Todorovski Izabela, Arnau Gisela Mir, Gadipally Sreeja, Yoannidis David, Simpson Kaylene J, Dong Xueyi, Whitehead Lachlan, Tempany Jessica C, Farchione Anthony J, Sheikh Amania A, Groom Joanna R, Rogers Kelly L, Herold Marco J, Bryant Vanessa L, Ritchie Matthew E, Willis Simon N, Johnstone Ricky W, Hodgkin Philip D, Nutt Stephen L, Vervoort Stephin J, Hawkins Edwin D
Abstract excerpt
High-throughput methodologies are the cornerstone of screening approaches to identify novel compounds that regulate immune cell function. To identify novel targeted therapeutics to treat immune disorders and haematological malignancies, there is a need to integrate functional cellular information with the molecular mechanisms that regulate changes in immune cell phenotype. We facilitate this goal by combining...
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