An integrative model of pathway convergence in genetically heterogeneous blast crisis chronic myeloid leukemia.

doi:10.1182/blood.2020004834

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Article

An integrative model of pathway convergence in genetically heterogeneous blast crisis chronic myeloid leukemia.

Blood - 25 Jun 2020

Ko Tun Kiat, Javed Asif, Lee Kian Leong, Pathiraja Thushangi N, Liu Xingliang, Malik Simeen, Soh Sheila Xinxuan, Heng Xiu Ting, Takahashi Naoto, Tan Joanna H J, Bhatia Ravi, Khng Alexis J, Chng Wee-Joo, Sia Yee Yen, Fruman David A, Ng King Pan, Chan Zhu En, Xie Kim Jiajing, Hoi Qiangze, Chan Cheryl Xueli, Teo Audrey S M, Velazquez Camacho Oscar, Meah Wee Yang, Khor Chiea Chuen, Ong Chin Thing J, Soon Wei Jia W, Tan Patrick, Ng Pauline C, Chuah Charles, Hillmer Axel M, Ong S Tiong

Abstract excerpt

Targeted therapies against the BCR-ABL1 kinase have revolutionized treatment of chronic phase (CP) chronic myeloid leukemia (CML). In contrast, management of blast crisis (BC) CML remains challenging because BC cells acquire complex molecular alterations that confer stemness features to progenitor populations and resistance to BCR-ABL1 tyrosine kinase inhibitors. Comprehensive models of BC transformation have...

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PMID: 32157296
DOI: 10.1182/blood.2020004834

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