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Article

Context-specific eQTLs provide deeper insight into causal genes underlying shared genetic architecture of COVID-19 and idiopathic pulmonary fibrosis.

HGG advances - 10 Apr 2025

Dalapati Trisha, Wang Liuyang, Jones Angela G, Cardwell Jonathan, Konigsberg Iain R, Bossé Yohan, Sin Don D, Timens Wim, Hao Ke, Yang Ivana, Ko Dennis C

Abstract excerpt

Most genetic variants identified through genome-wide association studies (GWASs) are suspected to be regulatory in nature, but only a small fraction colocalize with expression quantitative trait loci (eQTLs, variants associated with expression of a gene). Therefore, it is hypothesized but largely untested that integration of disease GWAS with context-specific eQTLs will reveal the underlying genes driving disease...

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Share to COVID-19
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Idiopathic Pulmonary Fibrosis

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

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Source

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Identifiers

PMID: 39876559
DOI: 10.1016/j.xhgg.2025.100410
PMCID: PMC11872446

Genes

ATP11A
DPP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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