Article
Human Lung DNA Methylation Quantitative Trait Loci Colocalize with Chronic Obstructive Pulmonary Disease Genome-Wide Association Loci.
American journal of respiratory and critical care medicine - 15 May 2018
Morrow Jarrett D, Glass Kimberly, Cho Michael H, Hersh Craig P, Pinto-Plata Victor, Celli Bartolome, Marchetti Nathaniel, Criner Gerard, Bueno Raphael, Washko George, Choi Augustine M K, Quackenbush John, Silverman Edwin K, DeMeo Dawn L
Abstract excerpt
RATIONALE: As the third leading cause of death in the United States, the impact of chronic obstructive pulmonary disease (COPD) makes identification of its molecular mechanisms of great importance. Genome-wide association studies (GWASs) have identified multiple genomic regions associated with COPD. However, genetic variation only explains a small fraction of the susceptibility to COPD, and sub-genome-wide...
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