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Article

PARP1 Val762Ala polymorphism reduces enzymatic activity.

Biochemical and biophysical research communications - 2 Mar 2007

Wang Xiao-Gan, Wang Zhao-Qi, Tong Wei-Min, Shen Yan

Abstract excerpt

Poly(ADP-ribose) polymerase 1 (PARP1) modifies a variety of nuclear proteins by poly(ADP-ribosyl)ation, and plays diverse roles in molecular and cellular processes. A common PARP1 single nucleotide polymorphism (SNP) at codon 762, resulting in the substitution of alanine (Ala) for valine (Val) in the catalytic domain has been implicated in susceptibility to cancer. To characterize the functional effect of this...

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Identifiers

PMID: 17214964
DOI: 10.1016/j.bbrc.2006.12.162

Genes

PARP1

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