Article
Using Human Induced Pluripotent Stem Cell-Derived Organoids to Identify New Pathologies in Patients With PDX1 Mutations.
Gastroenterology - 1 Oct 2022
Krishnamurthy Mansa, Kechele Daniel O, Broda Taylor, Zhang Xinghao, Enriquez Jacob R, McCauley Heather A, Sanchez J Guillermo, McCracken Kyle, Palermo Joseph, Bernieh Anas, Collins Margaret H, Thomas Inas H, Neef Haley C, Heider Amer, Dauber Andrew, Wells James M
Abstract excerpt
BACKGROUND & AIMS: Two patients with homozygous mutations in PDX1 presented with pancreatic agenesis, chronic diarrhea, and poor weight gain, the causes of which were not identified through routine clinical testing. We aimed to perform a deep analysis of the stomach and intestine using organoids derived from induced pluripotent stem cells from PDX1188delC/188delC patients. METHODS: Gastric fundic, antral, and...
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