Article

Human Gastric Multi-Regional Assembloids Favour Functional Parietal Maturation and Allow Modelling of Antral Foveolar Hyperplasia

2024-07-11

Abstract excerpt

Patient-derived human organoids have the remarkable capacity to self-organise into more complex structures. However, to what extent gastric organoids can recapitulate human stomach physiological functions remain unexplored. Here, we report how region-specific gastric organoids can self-assemble into complex multi-regional assembloids showing functional response to drugs targeting the ATPase H+/K+ pump. The assembl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 729933c3-b2a2-56d1-a925-e9b25633e999
DOI: 10.1101/2024.07.08.602480

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human Gastric Multi-Regional Assembloids Favour Functional Parietal Maturation and Allow Modelling of Antral Foveolar HyperplasiaDOI 10.1101/2024.07.08.602480Read

Using Human Induced Pluripotent Stem Cell Derived Organoids to Identify New Pathologies in Patients with PDX1 MutationsSemantic proximity Read

A human multilineage gut organoid model for Parkinson diseaseSemantic proximity Read

Using Human Induced Pluripotent Stem Cell-Derived Organoids to Identify New Pathologies in Patients With PDX1 Mutations.Semantic proximity Read

Type 1 diabetes human enteroid studies reveal major changes in the intestinal epithelial compartmentSemantic proximity Read

Therapy Development for Microvillus Inclusion Disease using Patient-derived EnteroidsSemantic proximity Read

Engineering functional human gastrointestinal organoid tissues using the three primary germ layers separately derived from pluripotent stem cellsSemantic proximity Read

Accessible homeostatic gastric organoids reveal secondary cell type-specific host-pathogen interactions in Helicobacter pylori infectionsSemantic proximity Read

Modelling human development and disease in pluripotent stem-cell-derived gastric organoidsSemantic proximity Read

Human gastrointestinal epithelia of the esophagus, stomach, and duodenum resolved at single-cell resolutionSemantic proximity Read

Generation of gastric insulin-secreting organoids from human stomach sampleSemantic proximity Read

Gastric Stem Cells: Physiological and Pathological PerspectivesSemantic proximity Read

Acid and the basis for cellular plasticity and reprogramming in gastric repair and cancerSemantic proximity Read