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Article

High expression of HMGA2 independently predicts poor clinical outcomes in acute myeloid leukemia

19 Jul 2018

Abstract excerpt

In acute myeloid leukemia (AML), risk stratification based on cytogenetics and mutation profiling is essential but remains insufficient to select the optimal therapy. Accurate biomarkers are needed to improve prognostic assessment. We analyzed RNA sequencing and survival data of 430 AML patients and identified HMGA2 as a novel prognostic marker. We validated a quantitative PCR test to study the association of...

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PMID: 30061630
DOI: 10.1038/s41408-018-0103-6

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