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Article

GATA2 links stemness to chemotherapy resistance in acute myeloid leukemia

22 Jan 2025

Abstract excerpt

ABSTRACT: Stemness-associated cell states are linked to chemotherapy resistance in acute myeloid leukemia (AML). We uncovered a direct mechanistic link between expression of the stem cell transcription factor GATA2 and drug resistance. The GATA-binding protein 2 (GATA2) plays a central role in blood stem cell generation and maintenance. We find substantial intrapatient and interpatient variability in GATA2...

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PMID: 39841459
DOI: 10.1182/blood.2024025761

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