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Chlorambucil-conjugated PI-polyamides (Chb-M'), a transcription inhibitor of RUNX family, has an anti-tumor activity against SHH-type medulloblastoma with p53 mutation.

Biochemical and biophysical research communications - 10 Sept 2022

Matsui Yasuzumi, Mineharu Yohei, Noguchi Yuki, Hattori Etsuko Yamamoto, Kubota Hirohito, Hirata Masahiro, Miyamoto Susumu, Sugiyama Hiroshi, Arakawa Yoshiki, Kamikubo Yasuhiko

Abstract excerpt

Malignancy of medulloblastoma depends on its molecular classification. Sonic Hedgehog (SHH)-type medulloblastoma with p53 mutation was recognized as one of the most aggressive types of tumors. We developed a novel drug, chlorambucil-conjugated PI-polyamides (Chb-M'), which was designed to compete with the RUNX consensus DNA-binding site. Chb-M' specifically recognizes this consensus sequence and alkylates it to...

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Identifiers

PMID: 35792512
DOI: 10.1016/j.bbrc.2022.06.090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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