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The long isoform of PRLR promotes tumor progression by regulating CDK6 through MAPK signal pathway in SHH medulloblastoma

2025-01-02

Abstract excerpt

<title>Abstract</title> <p>Medulloblastoma (MB) is the most common malignant brain tumors in children. Sonic Hedgehog (SHH) subgroup of MB accounts for about 25% of all MBs. SMO inhibitors are used for target therapy. However, drug resistance and toxicity occurred. New therapeutic targets are urgently needed to be developed. Here, through RNA-sequencing and Nanostring Assay analysis of primary MBs, we screened ou...

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Literature Corpus work
4755f26d-cfc7-5331-b440-3c7d3ce3dc35
DOI
10.21203/rs.3.rs-5667015/v1
Open publication

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The long isoform of PRLR promotes tumor progression by regulating CDK6 through MAPK signal pathway in SHH medulloblastomaDOI 10.21203/rs.3.rs-5667015/v1
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