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Article

Complete and sustained response of adult medulloblastoma to first-line sonic hedgehog inhibition with vismodegib

12 Aug 2016

Abstract excerpt

Medulloblastoma is an aggressive primitive neuroectodermal tumor of the cerebellum that is rare in adults. Medulloblastomas fall into 4 prognostically significant molecular subgroups that are best defined by experimental gene expression profiles: the WNT pathway, sonic hedgehog (SHH) pathway, and subgroups 3 and 4 (non-SHH/WNT). Medulloblastoma of adults belong primarily to the SHH category. Vismodegib, an...

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PMID: 27682250
DOI: 10.1080/15384047.2016.1220453

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