Article

BAY 11-7082 Ubiquitinates EGFR and Induces Apoptosis in SHH-MB via PI3K-AKT and STAT3 Pathways

2025-10-08

Abstract excerpt

<title>Abstract</title> <p>Medulloblastoma (MB), the most common malignant pediatric brain tumor, is classified into four molecular subgroups: Wnt, Sonic Hedgehog (SHH), Group 3 (G3), and Group 4 (G4). SHH-MB accounts for approximately one-third of cases. Current standard therapies—surgical resection, radiotherapy, and chemotherapy—remain limited by drug resistance and tumor recurrence, necessitating urgent explo...

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Literature Corpus work: 904503cf-2d74-5917-ae68-23cbc538f597
DOI: 10.21203/rs.3.rs-7227454/v1

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