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Article

Minos: variant adjudication and joint genotyping of cohorts of bacterial genomes.

Genome biology - 5 Jul 2022

Hunt Martin, Letcher Brice, Malone Kerri M, Nguyen Giang, Hall Michael B, Colquhoun Rachel M, Lima Leandro, Schatz Michael C, Ramakrishnan Srividya, Iqbal Zamin

Abstract excerpt

There are many short-read variant-calling tools, with different strengths and weaknesses. We present a tool, Minos, which combines outputs from arbitrary variant callers, increasing recall without loss of precision. We benchmark on 62 samples from three bacterial species and an outbreak of 385 Mycobacterium tuberculosis samples. Minos also enables joint genotyping; we demonstrate on a large (N=13k) M....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35791022
DOI: 10.1186/s13059-022-02714-x
PMCID: PMC9254434

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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