Article

Identifying indels from WGS short reads of haploid genomes distinguishes variant-calling algorithms

2022-12-16

Abstract excerpt

Identification of clinically relevant strains of bacteria increasingly relies on whole genome sequencing. The downstream bioinformatics steps necessary for calling variants from short read sequences are well-established but seldom validated against haploid genomes. We devised an in silico workflow to introduce single nucleotide polymorphisms (SNP) and indels into bacterial reference genomes, and computationally g...

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Literature Corpus work: f5a3fb21-a1ba-5c4c-a8dc-c51a37dccc32
DOI: 10.1101/2022.12.14.520524

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