Comprehensive and accurate genetic variant identification from contaminated and low-coverage Mycobacterium tuberculosis whole genome sequencing data

Abstract excerpt

Improved understanding of the genomic variants that allow Mycobacterium tuberculosis ( Mtb ) to acquire drug resistance, or tolerance, and increase its virulence are important factors in controlling the current tuberculosis epidemic. Current approaches to Mtb sequencing, however, cannot reveal Mtb ’s full genomic diversity due to the strict requirements of low contamination levels, high Mtb sequence coverage and...

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