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Article

Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice.

Proceedings of the National Academy of Sciences of the United States of America - 26 Dec 2012

Wang I-Ting Judy, Allen Megan, Goffin Darren, Zhu Xinjian, Fairless Andrew H, Brodkin Edward S, Siegel Steve J, Marsh Eric D, Blendy Julie A, Zhou Zhaolan

Abstract excerpt

Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene have been identified in neurodevelopmental disorders including atypical Rett syndrome (RTT), autism spectrum disorders (ASDs), and early infantile epileptic encephalopathy. The biological function of CDKL5 and its role in the etiology of these disorders, however, remain unclear. Here we report the development of a unique knockout mouse model of...

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Source

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Identifiers

PMID: 23236174
DOI: 10.1073/pnas.1216988110
PMCID: PMC3535652

Genes

CDKL5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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